tlr۸ and tlr۹ polymorphisms and pulmonary tuberculosis

Cytokines Genes Polymorphisms in Iranian Patients with Pulmonary Tuberculosis

Background: Pulmonary tuberculosis (PTB) has recently become a major problem in developed countries especially in immune compromised HIV infected individuals. Cytokines, their genes and receptors have been implicated in the protective immunity, pathophysiology and development of tuberculosis.   Material & Methods: In the present study the genotype frequencies of a number of polymorphic genes co...

BCG vaccine and pulmonary tuberculosis

Tuberculosis (TB) is one of the most important public health problems in the world and has been declared as a global emergency by the World Health Organization (WHO) in 1993. Bacillus Calmette-Guérin (BCG) is one of the first developed vaccines to prevent TB. Unfortunately, BCG vaccine has had a limited duration of protection and has shown controversial and variable levels of efficacy, especial...

association between tlr8 and tlr9 gene polymorphisms and pulmonary tuberculosis

conclusions tlr8 rs3764880 and tlr9 rs148805533 polymorphisms may not be risk factors for susceptibility to tuberculosis in a sample of iranian population. larger studies are required to validate our findings. results the allelic and genotypic frequencies of the tlr8 rs3764880 did not differ significantly between ptb and the controls. no significant difference was found between the groups regar...

Lack of Association Between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...

Pulmonary Tuberculosis

Prevalence and treatment outcome of pulmonary and extra pulmonary pediatric tuberculosis in southwestern Iran

 Background: Knowledge about childhood tuberculosis (TB) in Iran is limited. This study aimed to determine the proportion of tuberculosis in children living in Khuzestan in southwest of Iran and its treatment outcomes.  Methods: In this retrospective study, the child’s medical records registered in national TB program (NTP) unit of Khuzestan Health Center (KHC) for TB treatment from 2005 to ...